• Eligibilty
  • Page | 21 Volume 1 Issue 1 | January 2024 | ORIENTAL JOURNAL OF MEDICINE AND NATURAL SCIENCES
  • Inclusion criteria
    		•

    Oriental journal of medicine and natural sciences




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    Materials and methods 
    The systematic review adhered to the guidelines outlined in the Preferred 
    Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement 
    [15]. The study protocol was registered in the International Prospective Register 
    of Systematic Reviews (PROSPERO)
    Eligibilty 
    The general eligibility criteria for study inclusion were defined using the 
    "PICO" strategy: 
    “Population”: Immunocompetent children and young adults, of any gender, race, 
    or ethnicity, diagnosed with primary herpetic gingivostomatitis. The diagnosis 
    was confirmed through both clinical history and laboratory investigation. 
    "Intervention": Any systemic, topical, or physical therapy intended for the 
    treatment of primary herpetic gingivostomatitis (the intervention could be a 
    single approach or a combination of interventions). 
    "Comparison": Placebo, no intervention, or another active intervention. 
    "Outcomes": (a) Time of healing for oral and extraoral lesions, drooling, eating 
    and drinking difficulties, and fever. (b) Severity of oral lesions, measured by 
    changes in the number of lesions from the time of intervention administration. (c) 

    Page | 21 
    Volume 1 Issue 1
     | 
    January 2024 
    |
     
    ORIENTAL JOURNAL OF MEDICINE AND NATURAL SCIENCES 
    “Innovative World” Scientific Research Support Center www.inno-world.uz
    Eating and drinking ability. (d) Pain, assessed using a validated pain scale. (e) 
    Viral shedding. (f) HSV quantification. (g) Evaluation of biomarkers. 
    Inclusion criteria 
    Eligible studies included randomized trials evaluating the impact of any 
    therapeutic approach for treating primary herpetic gingivostomatitis (PHGS), 
    along with non-randomized intervention studies, controlled before-after studies, 
    and observational studies such as prospective and retrospective cohort studies, 
    case–control studies, and cross-sectional studies. 

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    Oriental journal of medicine and natural sciences

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