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A systematic review on supportive care and antiviralBog'liq 3. Yakubova,Dusmurodova
A systematic review on supportive care and antiviral
interventions in primary herpetic gingivostomatitis
Yakubova Farida Khaldarovna
Associate professor of Alfraganus university
Email: farida.xaldarovna@gmail.com
ORCID ID:0000-0003-3727-4497
Dusmurodova Khumora Otabekovna
Assistant teacher of Alfraganus University
ARTICLE INFO
Received: 15
th
January 2024
Accepted: 15
th
January 2024
Online: 16
th
January 2024
ABSTRACT
With the rapid development of metagenomic high-
throughout sequencing technology, more and more oral
mucosal diseases have been proven to be associated
with oral microbiota shifts or dysbiosis. The commensal
oral microbiota can greatly influence the colonization
and resistance of pathogenic microorganisms and
induce primary immunity. Once dysbiosis occurs, it can
lead to damage to oral mucosal epithelial defense, thus
accelerating the pathological process. As common oral
mucosal diseases, oral mucositis and ulcers seriously
affect patients’ prognosis and quality of life. However,
from the microbiota perspective, the etiologies, specific
alterations of oral flora, pathogenic changes, and
therapy for microbiota are still lacking in a
comprehensive overview. This review makes a
retrospective summary of the above problems,
dialectically based on oral microecology, to provide a
new perspective on oral mucosal lesions management
and aims at improving patients’ quality of life.
KEY WORDS
oral microbiota, dysbiosis, oral
mucositis, recurrent aphthous
stomatitis (RAS), probiotics
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